职 称：讲师

学 历：博士

E-mail:huyuchen@hbut.edu.cn

研究方向：功能性多肽的合成与应用、多肽大环化方法学开发

工作经历：

2012.09-2016.06四川大学药学专业学士

2016.09-2022.06重庆大学化学工程与技术专业硕博连读博士

2022.08-至今湖北工业大学讲师

研究课题：

项目“新型阳离子桥联抗菌肽的合成及其抗炎症作用研究”国家自然科学基金面上项目2021.01-2024.12在研、参与

研究成果：

1.Hu Y,Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. Journal of Medicinal Chemistry, 2022, 65(1): 579-591.

2. Li H,Hu Y, Pu Q, He T, Zhang Q, Wu W, Xia X, Zhang J. Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides.Journal of Medicinal Chemistry,2020, 63(8): 4081-4089.

3.HeT,Xu L,Hu Y, Tang X, Qu R, Zhao X, Bai H, Li L, Chen W, Luo G, Fu G, Wang W, Xia X, Zhang J. Lysine-Tethered Stable Bicyclic Cationic Antimicrobial Peptide Combats Bacterial Infection in Vivo.Journal of Medicinal Chemistry,2022, 65(15): 10523–10533

4. Fan Y, Wu W, Luo T,Hu Y, Zhang Q, Zhang J, Xia X. Cross-Linking of S-Nitrosothiolated AIEgens Inside Cancer Cells to Monitor NO Release and Reverse Chemo-Resistance. Chemical Communications, 2021, 57(93): 12520-12523.