一、团队名称
中德生物医学中心
二、团队组成
负责人：胡康洪(博士、主任、二级教授)
成员：副教授（博士）2名、讲师（博士）1名、实验员（硕士）1名
三、团队介绍
本中心围绕影响人类健康和新发传染病病原的研究领域，在“病毒致病机理及抗病毒药物研发”及“干细胞介导的再生医学”等科学前沿致力于原始创新。主要研究内容为以乙型肝炎病毒（HBV）、致手足口病的肠道病毒71型（EV71）等高致病、高传染性病毒为研究对象，应用生物信息学方法、体外细胞培养系统、动物模型、人体组织四大系统，有机整合病毒学、医学、化学和药学等优势学术力量，阐明病毒感染复制机理，寻找具有新颖结构、优良抗病毒活性、新颖抗病毒机制的特异高效抗病毒药物，为病毒性疾病治疗奠定理论基础及开辟应用前景。另外，以独创的Hu3D®三维培养系统为平台，探索干细胞介导的肝肾组织再生、器官修复等再生医学前沿领域。
团队承担了国家“十一五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项、国家“十二五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项、国家自然科学基金面上项目、国家自然科学基金青年项目、湖北省自然科学基金重点项目、各类校企合作项目等，累计科研经费逾2000万元。
近五年发表SCI论文22篇，出版学术专著1本，获授权发明专利7项，培养博士研究生2名（与中科院合招）、硕士研究生11名，2018年和2019年分获中国人民解放军全军科技进步奖二等奖、中华预防医学会科技进步奖三等奖各1项。
四、科研成果
（1）代表性科研项目
1.国家“十一五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项，2008ZX10002-011，乙型病毒性肝炎病毒感染模型，2008.10-2010.12，结题，子课题主持。
2.国家自然科学基金面上项目，3087013，SELEX技术筛选抗HBV的诱饵分子，2009.01-2011.12，结题，主持。
3.国家“十二五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项，2012ZX10004508-008，HBV感染细胞和动物模型的建立和应用，2012.01-2015.12，结题，子课题主持。
4.国家自然科学基金青年项目，31400153，PI3K/Akt信号通路在DHEA衍生物抗EV71中的作用研究，2015.01-2017.12，结题，主持。
5.湖北省自然科学基金重点项目，2014CFA075，RNA诱饵分子抗HBV功效的体内研究，2015.01-2017.12，结题，主持。
6.校企合作项目“Hu3D®三维灌流式培养仪产业化”常州康珞生物科技公司委托2018.01-2022.12，在研，主持
7.校企合作项目“新一代抗衰老干细胞抽提液”武汉润禾生物医药有限公司委托2018.01-2020.12，在研，主持
（2）代表性成果获奖
1.中国人民解放军全军科技进步奖二等奖“乙型病毒性肝炎肝硬化的基础与临床研究”2018年（排名第二）
2.中华预防医学会科学技术奖三等奖“乙型肝炎病毒细胞模型与乙型肝炎治疗新策略研究”2019年（排名第二）
（3）代表性论文及专著
1.Yanhong Wei, Haijie Wang, Caili Xi, Ni Li, Dong Li, Chenguang Yao, Ge Sun, Hongmei Ge,Kanghong Hu*, Qian Zhang* 2020 “Antiviral effects of novel 2-benzoxyl-phenylpyridine derivatives”Molecules25,1409; doi:10.3390/molecules25061490
2.胡康洪参编《中国学科发展战略再生医学》科学出版社2020年ISBN 9787030434005
3.Xiaokang Hu, Huan Wang, Bo Huang, Ni Li,Kanghong Hu*et al.2019 “A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities”Journal of Inorganic Biochemistry193:130-132 doi: 10.1016/J.JINORGBIO.2019.01.013
4.Yao Chengguang#,Hu Kanghong#et al.2019 “Transcriptomic analysis of cells in response to EV71 infection and 2Apro as a trigger for apoptosis via TXNIP gene”Genes & Genomics41(3):343-357. doi: 10.1007/s13258-018-0760-7
5.Yao Chengguang, Xi Caili,Hu Kanghong, Gao Wa, Cai Xiaofeng, Qin Jinlan, Lv Shiyun, Du Canghao,Wei Yanhong*2018 “Inhibition of enterovirus 71 replication and viral 3C protease by quercetin”Virology Journal15(1):116. doi: 10.1186/s12985-018-1023-6.
6.Cheng M, Li N, Wang N,Hu K, Xiao Z*, Wu P*,Wei Y*2018“Synthesis, structure and antitumor studies of a novel decavanadate complex with a wavelike two-dimensional network”Polyhedron155: 313-319. doi: 10.1016/J.POLY.2018.08.052
7.Ke S *, Li N, Ke T, Shi L, Zhang Z, Fang W, Zhang Y, Wang K, Zhou R, Wan Z, Yang Z, Zhang G,Wei Y*2018“Synthesis and evaluation of steroidal thiazoline conjugates as potential antiviral agents”Future MedicinalChemistry10 (22), 2589-2605.doi:10.4155/fmc-2018-0075
8.Ji M,Hu K*. 2017 “Recent advances in the study of hepatitis B virus covalently closed circular DNA”Virologica Sinica32(6):454-464 doi: 10.1007/S12250-017-4009-4
9.Ye Guoguo, Sun Ge, Cheng Zhikui, Zhang Lei,Hu Kanghong, Xia Xianmin*, Zhou Yin* 2017 “p55PIK regulates alpha-fetoprotein expression through the NF-kappa B signaling pathway”Life Sciences191:104-110 doi: 10.1016/J.LFS.2017.09.043
10.Peng Ke, Honghao Sun, Mingxing Liu, Zhengding Su,Kanghong Huet al. 2016 “Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide”IET Nanobiotechnology10( 1): 8-12 doi: 10.1049/IET-NBT.2014.0070
11.Cheng Z, Zhi X, Sun G, Guo W, Zhao F,Hu K*2016“Sodium selenite suppresses hepatitis B virus transcription and replication in human hepatoma cell lines”Journal ofMedicalVirology2016, 88(4): 653-663.doi: 10.1002/JMV.24366
12.Ye X, Zhou M, He Y, Wan Y, Bai W, Tao S, Ren Y, Zhang X, Xu J, Liu J, Zhang J*,Hu K*,Xie Y*2016Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide.ScientificReports6: 29391.doi: 10.1038/srep29391
13.Danzhen Pan , Yong Lin, Weimin Wu, Jingjiao Song, Ejuan Zhang, Chunchen Wu, Xinwen Chen,Kanghong Huet al.2015 “Persistence of the Recombinant Genomes of Woodchuck Hepatitis Virus in the Mouse Model”PloS One10(5):e0125658 doi: 10.1371/JOURNAL.PONE.0125658
14.Cheng Z, Sun G, Guo W, Huang Y, Sun W, Zhao F,Hu K*2015“Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines”VirologicaSinica2015, 30(4): 261- 268.doi: 10.1007/S12250-015-3584-5
15.Zhou M, Huang Y, Cheng Z, Zhao F, Li J, Zhi X, Tian X, Sun W,HuK*2014“Revival, characterization, and hepatitis B virus infection of cryopreserved human fetal hepatocytes”Journal ofVirologicalMethods2014, 207:29-37.doi: 10.1016/J.JVIROMET.2014.06.015
16.Zhou M, Zhao F, Li J, Cheng Z, Tian X, Huang Y, Zhi X andHu K*2014“Long-term maintenance of human fetal hepatocytes and prolonged susceptibility to HBV infection by co-culture with nonparenchymal cells”Journal ofVirologicalMethods195: 185-193.doi: 10.1016/J.JVIROMET.2013.10.010
17.Tian X, Zhao F, Sun W,Zhi X, Cheng Z, Zhou M,Hu K*2014“CRTC2 enhances HBV transcription and replication by inducing PGC1α expression”VirologyJournal11:30. doi: 10.1186/1743-422X-11-30.
18.Tian X, Zhao F, Cheng Z, Zhou M, Zhi X, Li J,Hu K*2013 “GCN5 acetyltransferase inhibits PGC1α-induced hepatitis B virus biosynthesis”Virologica Sinica28(4):216-222. doi: 10.1007/S12250-013-3344-3
19.Chen P, Yun G, Na H, Wei F, Li J, Zhao F, Rayner S*,Hu K*2013“Computational evolutionary analysis of the overlapped surface (S) and polymerase (P) region in hepatitis B virus indicates the spacer domain in P is crucial for survival”PloS One8(4): e60098.doi: 10.1371/JOURNAL.PONE.0060098
20.Feng H, Chen P, Zhao F, Nassal M*,Hu K*2013“Evidence for Multiple Distinct Interactions between Hepatitis B Virus P Protein and Its Cognate RNA Encapsidation Signal during Initiation of Reverse Transcription”Plos One, 2013, 8: e72798.doi: 10.1371/JOURNAL.PONE.0072798
21.Pan X, Li XJ, Liu XJ, Tian XH,Hu KH.et al.2013 “Later Passage Neural Progenitor Cells from Neonatal Brain Are More Permissive for Human Cytomegalovirus Infection”Journal of Virology87(20):10968-10979. doi: 10.1128/JVI.01120-13
22.Wang W, Peng H, Li J, Zhao X, Zhao F,Hu K*2013Controllable inhibition of hepatitis B virus replication by a DR1-targeting short hairpin RNA (shRNA) expressed from aDOX-inducible lentiviral vector.Virus Genes2013, 46(3): 393-403. doi: 10.1007/S11262-013-0886-2
23.Zhao Z, Hong W, Zeng Z, Wu Y,Hu Ket al.2012 “ucroporin-M1 inhibits hepatitis B virus replication by activating the MAPK pathawy and down-regulating HNF4α in vitro and in vivo”Journal of Biological Chemistry287(36):30181-90. doi:10.1074/jbc.M112.370312
24.Feng H , Beck J, Nassal M andHu K*2011“A SELEX-Screened aptamer of human hepatitis B virus RNA encapsidation signal suppresses viral replication”Plos One6(11): e27862.doi:10.1371/JOURNAL.PONE.0027862
25.Chen P , Rayner S*, andHu K*2011 “Advances of bioinformatics tools applied in virus epitopes prediction”Virologica Sinica26(1):1-7 doi: 10.1007/s12250-011-3159-4
26.Hu K*2010 “From Minu3D cultural system to aldosterone-induced tubulogenesis”Journal of Clinical Rehabilitative Tissue Engineering Research14(2):365-369 doi:10.3969/j.issn.1673-8225.2010.02.041
27.Feng H andHu K*2009 “Structural Characteristics and Molecular Mechanism of Hepatitis B Virus Reverse Transcriptase”Virologica Sinica24(6):509-517 doi: 10.1007/s12250-009-3076-6
28.Feng H andHu K*2008 “Aptamers against viral hepatitis from rational design to practical application”Virologica Sinica23(5):315-320 doi:10.1007/s12250-008-2979-y
29.Minuth WW, Denk L,Hu Ket al.2007 “The tubulogenic effect of aldosterone is attributed to intact binding and intracellular response of the mineralocorticoid receptor”Central European Journal of Biology2(3), 307-325 doi: 10.2478/S11535-007-0030-1
30.Minuth WW, Denk L andHu K2007 “The role of polyester interstitium and aldosterone during structural development of renal tubules in serum-free medium”Biomaterials28(30), 4418-4428 doi: 10.1016/J.BIOMATERIALS.2007.06.031
31.Heber S, Denk L,Hu K2007 “Modulating the development of renal tubules growing in serum-free culture medium at an artificial interstitium”Tissue Engineering13(2), 281-292 doi:10.1089/TEN.2006.0199
32.Hu Ket al.2007 “Chemically defined medium determines the differential potency of renal stem cells”Biotechnology Journal2(8), 992-995 doi:10.1002/BIOT.200700009
33.Hu Ket al.2005“Characterization of the human zinc finger protein 267 promoter: essential role of nuclear factor Y”BiochimicaBiophysicaActa2005,1729(1):14-23. doi:10.1016/J.BBAEXP.2005.03.001
34.Hu Ket al.2004“SELEX-derived aptamers of the duck hepatitis B virus RNA encapsidation signal distinguish critical and non-critical residues for productive initiation of reverse transcription”Nucleic Acids Research32(14):4377-4389. doi: 10.1093/NAR/GKH772
35.Fels A,Hu Ket al.2001 “Transcription of potato spindle tuber viroid by RNA polymerase II starts predominatly at two specific sites”Nucleic Acids Research29(22), 4589-4597 doi: 10.1093/NAR/29.22.4589
（4）代表性发明专利
1.胡康洪、冯辉、周明；一种抗HBV 诱饵适体及其筛选方法，2013-10-09，授权号ZL 201110410737.7
2.胡康洪、王薇薇、彭洪泉；利用慢病毒载体介导RNAi的方法2013-11-27，授权号ZL201110110644.2
3.胡康洪；一种三维灌流式细胞培养器，2014-07-23，授权号ZL201420033628.7
4.胡康洪、周明、曹晓蓓；人原代肝细胞与肝非实质细胞共培养方法，2015-02-18，授权号ZL201310282851.5
5.胡康洪、尧晨光、叶国国、朱祥、奚彩丽、成细瑶等；一种批量简易移液器枪头装盒装置，2017-10-03，授权号ZL201510596259.1
6.胡康洪、黄亚运、程智逵、孙鸽、魏艳红；N-甲酰基-3,4-亚甲二氧基苄基-γ-丁内酯在制备抗乙型肝炎病毒药物中的应用，2018-11-23，授权号ZL201610407438.0
7.魏艳红、李妮、胡康洪、吕诗韵、杜仓浩；氨基酸酯化合物在制备抗CVB3病毒药物中的应用,2020-1-7,授权号ZL201810751307.3.
8.魏艳红、奚彩丽、张谦、李栋、胡康洪、尧晨光；二芳基甲酮化合物在制备抗肿瘤药物中的应用，2019-4-26,授权号ZL 201611176431.9.
9.魏艳红、奚彩丽、胡康洪、张谦、李栋、尧晨光;芳香酯类化合物在制备抗肠道病毒71型药物中的应用,2018-11-13,授权号ZL 201611192748.1.
五、研究生毕业去向
1、博士研究生：与中科院联合培养的优秀毕业生进入省属三甲医院检验科工作或在985高校做博士后研究。
2、硕士研究生：
①攻读博士学位：推荐到某985高校免试攻读博士学位。
②企事业单位：推荐到中国生物医药集团等大型上市公司。
③报考公务员：考上政府部门公务员。
六、联系方式
联系人：孙老师
电话：027-59750462
邮箱：hukh@hbut.edu.cn
